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Depends on the bracket. One may have to use nitro earlier or if they're lucky they can save it for finals.
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Correct, if they do have an easier match up, saving nitro shouldn't be a problem. Paired with the 7-0-1 combo early, like 205 said above, nitro should prove to give a considerable advantage near round 3-4. Likewise, personally the 6-1-6 combo has proven to be quite strategic as well.