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Biological sex is not as straightforward as you think. You've got people who aren't XY-Male and XX-Female. There's people with XXY, a single X, an X paired with a partial X, 5-alpha-reductase deficiency, you name it.
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I had a friend (male) had some sort of weird thing going on with his chromosomes. Was a normal dude but his body didn't produce Test like it should've (that's as far as I know, prob had some other **** going on). So I wouldn't really say this is the whole gender thing people are concerned about.